Rebecca P. Hughey, Ph.D.
Research Interest: Studying two proteins expressed on the apical surface of polarized epithelial cells: (1) the biosynthesis, processing and proteolytic activation of the epithelial sodium channel (ENaC), and (2) the function and membrane trafficking of the mucin-like MUC1.


Polarized epithelial cells are characterized by a distinct population of proteins and lipids at the apical and basolateral surfaces. Research in the Hughey lab is focused on characterization of three distinct types of apical proteins, including a transmembrane mucin (MUC1), a heterotrimeric epithelial sodium channel (ENaC), and the small hydrolase, gamma-glutamyltranspeptidase (GGT). Using heterologous expression in cultured cell lines, we are characterizing the features of these proteins that regulate their maturation (including proteolytic and palmitoylation), delivery to the cell surface, and subsequent membrane trafficking.



Recent Publications: