Gerald P. Schatten, Ph.D.
Research Interest: Molecular basis of reproduction and development; Stem cells and transplantation

Dr. Schatten's research focuses on understanding human reproduction and development and making contributions to molecular medical therapies by determining stem cell potentials and accelerating gene therapy. Utilizing gametes, embryos and stem cells, Dr. Schatten and his research colleagues are aiming to answer questions regarding:

  • Human Reproduction (gametogenesis, contraception, assisted reproduction, genetic basis of infertility, male and female meiotic cell cycle regulation, and reproductive aging)
  • Human Development (Pre- and post-implantation development, body axis specification, somitogenesis, organogenesis, imprinting, extra-embryonic membrane allocation, pluripotency, dynamic noninvasive imaging of transgenic reporters)
  • Cloned Transgenic Disease Models (breast and ovarian cancers; inborn errors of metabolism; arteriosclerosis; infectious diseases; cognitive and mental disorders; Parkinson's and Huntington's diseases; polycystic kidney disease; blindness, deafness and sensory disorders; storage diseases, cystic fibrosis)
  • Stem Cell Potentials (diabetes; liver and kidney cells; wound healing; muscle and nerve)
  • Genetic versus Epigenetic (or environmental causes for human diseases)

Dr. Schatten is a founding course director of Frontiers in Human Embryonic Stem Cell Research (FrHESC) - an intensive laboratory and lecture-based introduction to this emerging research field. He was also a founding course director of Frontiers in Reproduction at the Marine Biology Laboratory in Woods Hole, Massachusetts, another program of modern bioscience techniques for beginning investigators in reproductive sciences. He is the only American on the executive committee of UNESCO's International Cell Research Organization. Along with extensive funding from the National Institutes of Health, Dr. Schatten is the recipient of a MERIT award and was recently honored by the Czech Academy of Sciences with the Purkinje Medal. His numerous authored and co-authored papers on fertilization, cell biology, development, infertility, and assisted reproductive technologies have appeared in premier journals such as Fertility and Sterility and Science. Dr. Schatten is also an eloquent advocate for research in reproduction, development, and stem cells and has testified to the US Senate and the President's Council on Bioethics.

  • 1: Simerly C, Castro C, Hartnett C, Lin CC, Sukhwani M, Orwig K, Schatten G. Post-Testicular Sperm Maturation: Centriole Pairs, Found in Upper Epididymis, are Destroyed Prior to Sperm's Release at Ejaculation. Sci Rep. 2016 Aug 18;6:31816. doi: 10.1038/srep31816. PubMed PMID: 27534805; PubMed Central PMCID: PMC4989225.
  • 2: Schatten G, Stearns T. Sperm Centrosomes: Kiss Your Asterless Goodbye, for Fertility's Sake. Curr Biol. 2015 Dec 21;25(24):R1178-81. doi: 10.1016/j.cub.2015.11.015. PubMed PMID: 26702655.
  • 3: Schatten G, Simerly C. LEGOsĀ® and legacies of centrioles and centrosomes. EMBO Rep. 2015 Sep;16(9):1052-4. doi: 10.15252/embr.201540875. Epub 2015 Aug 6. PubMed PMID: 26249334; PubMed Central PMCID: PMC4576973.
  • 4: Easley CA, Simerly CR, Schatten G. Gamete derivation from embryonic stem cells, induced pluripotent stem cells or somatic cell nuclear transfer-derived embryonic stem cells: state of the art. Reprod Fertil Dev. 2014 Dec;27(1):89-92. doi: 10.1071/RD14317. Review. PubMed PMID: 25472048; PubMed Central PMCID: PMC4346179.
  • 5: Zhang X, Simerly C, Hartnett C, Schatten G, Smithgall TE. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13(3 Pt A):379-89. doi: 10.1016/j.scr.2014.09.007. Epub 2014 Sep 30. PubMed PMID: 25305536; PubMed Central PMCID: PMC4252886.
  • 6: Thompson WE, Pattillo RA, Stiles JK, Schatten G. Biomedical research's unpaid debt: NIH's initiative to support and implement fairer competition for minority students is a welcome step to redress the exploitation of African Americans by science. EMBO Rep. 2014 Apr;15(4):333-7. doi: 10.1002/embr.201338274. Epub 2014 Mar 20. PubMed PMID: 24652854; PubMed Central PMCID: PMC3983679.
  • 7: Huleihel L, Ben-Yehudah A, Milosevic J, Yu G, Pandit K, Sakamoto K, Yousef H, LeJeune M, Coon TA, Redinger CJ, Chensny L, Manor E, Schatten G, Kaminski N. Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L534-42. doi: 10.1152/ajplung.00149.2013. Epub 2014 Jan 17. PubMed PMID: 24441869; PubMed Central PMCID: PMC3949080.
  • 8: Easley CA 4th, Latov DR, Simerly CR, Schatten G. Adult somatic cells to the rescue: nuclear reprogramming and the dispensability of gonadal germ cells. Fertil Steril. 2014 Jan;101(1):14-9. doi: 10.1016/j.fertnstert.2013.11.025. Review. PubMed PMID: 24382340; PubMed Central PMCID: PMC4285723.
  • 9: Easley CA 4th, Simerly CR, Schatten G. Stem cell therapeutic possibilities: future therapeutic options for male-factor and female-factor infertility? Reprod Biomed Online. 2013 Jul;27(1):75-80. doi: 10.1016/j.rbmo.2013.03.003. Epub 2013 Mar 26. Review. PubMed PMID: 23664220; PubMed Central PMCID: PMC3703485.
  • 10: Cibelli J, Emborg ME, Prockop DJ, Roberts M, Schatten G, Rao M, Harding J, Mirochnitchenko O. Strategies for improving animal models for regenerative medicine. Cell Stem Cell. 2013 Mar 7;12(3):271-4. doi: 10.1016/j.stem.2013.01.004. PubMed PMID: 23472868; PubMed Central PMCID: PMC4383280.
  • 11: Shi Q, Schatten G, Hodara V, Simerly C, VandeBerg JL. Endothelial reconstitution by CD34+ progenitors derived from baboon embryonic stem cells. J Cell Mol Med. 2013 Feb;17(2):242-51. doi: 10.1111/jcmm.12002. Epub 2013 Jan 10. PubMed PMID: 23301772; PubMed Central PMCID: PMC3814022.
  • 12: Schatten G. Cellular promiscuity: explaining cellular fidelity in vivo against unrestrained pluripotency in vitro. EMBO Rep. 2013 Jan;14(1):4. doi: 10.1038/embor.2012.198. Epub 2012 Dec 11. Erratum in: EMBO Rep. 2013 Feb;14(2):212. PubMed PMID: 23229589; PubMed Central PMCID: PMC3537150.
  • 13: Hermann BP, Sukhwani M, Winkler F, Pascarella JN, Peters KA, Sheng Y, Valli H, Rodriguez M, Ezzelarab M, Dargo G, Peterson K, Masterson K, Ramsey C, Ward T, Lienesch M, Volk A, Cooper DK, Thomson AW, Kiss JE, Penedo MC, Schatten GP, Mitalipov S, Orwig KE. Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell. 2012 Nov 2;11(5):715-26. doi: 10.1016/j.stem.2012.07.017. PubMed PMID: 23122294; PubMed Central PMCID: PMC3580057.
  • 14: Shi Q, Hodara V, Simerly CR, Schatten GP, VandeBerg JL. Ex vivo reconstitution of arterial endothelium by embryonic stem cell-derived endothelial progenitor cells in baboons. Stem Cells Dev. 2013 Feb 15;22(4):631-42. doi: 10.1089/scd.2012.0313. Epub 2012 Oct 10. PubMed PMID: 22931470; PubMed Central PMCID: PMC3564485.
  • 15: Easley CA 4th, Phillips BT, McGuire MM, Barringer JM, Valli H, Hermann BP, Simerly CR, Rajkovic A, Miki T, Orwig KE, Schatten GP. Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Rep. 2012 Sep 27;2(3):440-6. doi: 10.1016/j.celrep.2012.07.015. Epub 2012 Aug 23. PubMed PMID: 22921399; PubMed Central PMCID: PMC3698576.
  • 16: Simerly C, Schatten G. Utility of animal models for human embryo culture: nonhuman primates. Methods Mol Biol. 2012;912:39-59. doi: 10.1007/978-1-61779-971-6_4. PubMed PMID: 22829368.
  • 17: Guha D, Nagilla P, Redinger C, Srinivasan A, Schatten GP, Ayyavoo V. Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells. J Neuroinflammation. 2012 Jun 22;9:138. doi: 10.1186/1742-2094-9-138. PubMed PMID: 22727020; PubMed Central PMCID: PMC3425332.
  • 18: Easley CA 4th, Miki T, Castro CA, Ozolek JA, Minervini CF, Ben-Yehudah A, Schatten GP. Human amniotic epithelial cells are reprogrammed more efficiently by induced pluripotency than adult fibroblasts. Cell Reprogram. 2012 Jun;14(3):193-203. doi: 10.1089/cell.2011.0106. PubMed PMID: 22686477; PubMed Central PMCID: PMC4361010.
  • 19: Shweiki D, Ben-Yehudah A, Redinger C, Easley CA 4th, Doron S, Schatten G. Sexually dimorphic gene expression in non-human primate ESCs analyzed stringently. Biochem Biophys Res Commun. 2011 Oct 28;414(3):631-4. doi: 10.1016/j.bbrc.2011.09.139. Epub 2011 Oct 6. PubMed PMID: 22005468.
  • 20: Varum S, Rodrigues AS, Moura MB, Momcilovic O, Easley CA 4th, Ramalho-Santos J, Van Houten B, Schatten G. Energy metabolism in human pluripotent stem cells and their differentiated counterparts. PLoS One. 2011;6(6):e20914. doi: 10.1371/journal.pone.0020914. Epub 2011 Jun 17. PubMed PMID: 21698063; PubMed Central PMCID: PMC3117868.