Ora A. Weisz, Ph.D.
Research Interest: Regulation of apical membrane traffic in renal epithelial cells

We use imaging, biochemical, genomic, and modeling approaches to study the regulation of apical membrane traffic in the kidney proximal tubule. Robust apical endocytosis is an essential function of proximal tubule cells and defects in this pathway cause tubular proteinuria that can lead to end stage kidney disease. We are working to identify the compartments and machinery that mediate apical endocytosis in these highly specialized cells, to understand how this pathway is regulated by physiologic stimuli including mechanosensitive cues, and to determine the molecular basis of genetic disorders and other diseases that result in tubular proteinuria.

Recent Publications: