CBMP People
CBMP Faculty
Rebecca P. Hughey, Ph.D.
Title: Professor
Department: Medicine, Renal-Electrolyte
Email: hugheyr@pitt.edu
PubMed: Link
Dept / Lab Webpage: http://www.dom.pitt.edu/renal/faculty_info.aspx/Hughey5103
CBMP groups: Membrane Traffic of Proteins and Lipids, Cell Communication, Signaling and Ion Channel Biology
Department: Medicine, Renal-Electrolyte
Email: hugheyr@pitt.edu
PubMed: Link
Dept / Lab Webpage: http://www.dom.pitt.edu/renal/faculty_info.aspx/Hughey5103
CBMP groups: Membrane Traffic of Proteins and Lipids, Cell Communication, Signaling and Ion Channel Biology
Research Interests
Polarized epithelial cells are characterized by a distinct population of proteins and lipids at the apical and basolateral surfaces. Research in the Hughey lab is focused on characterization of three distinct types of apical proteins, including a transmembrane mucin (MUC1), a heterotrimeric epithelial sodium channel (ENaC), and the small hydrolase, gamma-glutamyltranspeptidase (GGT). Using heterologous expression in cultured cell lines, we are characterizing the features of these proteins that regulate their maturation (including proteolytic and palmitoylation), delivery to the cell surface, and subsequent membrane trafficking.