Cell Biology and Molecular Physiology

University of Pittsburgh School of Medicine - Interdisciplinary Biomedical Graduate Program

CBMP Faculty

Rebecca P. Hughey, Ph.D.

Image - Rebecca P. Hughey

Research Interests

Polarized epithelial cells are characterized by a distinct population of proteins and lipids at the apical and basolateral surfaces. Research in the Hughey lab is focused on characterization of three distinct types of apical proteins, including a transmembrane mucin (MUC1), a heterotrimeric epithelial sodium channel (ENaC), and the small hydrolase, gamma-glutamyltranspeptidase (GGT). Using heterologous expression in cultured cell lines, we are characterizing the features of these proteins that regulate their maturation (including proteolytic and palmitoylation), delivery to the cell surface, and subsequent membrane trafficking.