Studying two proteins expressed on the apical surface of polarized epithelial cells: (1) the biosynthesis, processing and proteolytic activation of the epithelial sodium channel (ENaC), and (2) the function and membrane trafficking of the mucin-like MUC1.
Mechanisms underlying the initiation and maintenance of cardiac arrhythmias; development of genetically encoded Ca2+ and voltage sensitive probes, rescuing the infarcted hearts with cell implants; sex differences in ion channel expression and their related arrhythmia phenotype in the long QT syndrome; high-speed depth-resolved images of electrical activity.