University of Pittsburgh School of Medicine - Interdisciplinary Biomedical Graduate Program
Our laboratory is working on the molecular mechanisms and cellular stress responses that allow a cell to adapt to metabolic alterations. Currently, we are focused on the metabolite acetyl-CoA, which plays a central role in the biosynthesis of various biomaterials, as well as in protein acetylation. We developed an experimental system to manipulate acetyl-CoA levels in cells and organisms and are investigating acetyl-CoA fluctuation-dependent functional alterations in organelles (including nucleoli, ER, mitochondria and lysosomes) and the subsequent activation of organelle-associated stress signaling pathways. A long-term goal is to understand the sensing mechanisms for various metabolite fluctuations in cells and to reveal their relevance to human aging and age-related diseases.
Key questions defining research program